1673: European explorers Father Jacques Marquette and Louis Jolliet first set foot in Missouri.
1719: Mining for lead and silver in the Mine La Motte area begins near current-day Fredericktown.
1724: Fort Orleans is constructed along the Missouri River near current-day Brunswick.
1735: French lead miners established the first permanent white settlement at Sainte Genevieve.
1750: Ste. Genevieve established.
1764: St. Louis is established by Pierre Laclede Liguest and Rene August Chouteau
1769: St. Charles established by Louis Blanchette.
1774 – First school opens in St. Louis.
1796 – Daniel Boone settles near Femme Osage Creek in St. Charles County.
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