| City | County | 2021 Pop. | 2000 Pop. |
|---|---|---|---|
| #1 Kansas City | Jackson | 508,394 | 442,307 |
| #2 St. Louis | City | 293,310 | 346,937 |
| #3 Springfield | Greene | 169,724 | 152,587 |
| #4 Columbia | Boone | 126,853 | 86,062 |
| #5 Independence | Jackson | 122,088 | 113,609 |
| #6 Lee’s Summit | Jackson | 102,781 | 71,248 |
| #7 O’Fallon | St. Charles | 93,644 | 50,770 |
| #8 St. Joseph | Buchanan | 71,602 | 74,126 |
| #9 St. Charles | St. Charles | 70,820 | 59,996 |
| #10 St. Peters | St. Charles | 58,129 | 50,798 |
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